What is the Origin of Methylation Pattern Correction?

Rooted in epigenetics and biochemistry, methylation is the critical process of adding a methyl group to DNA, a major mechanism for gene silencing. Correction is the therapeutic goal of reversing the errors that accumulate in these patterns over time, which are strongly correlated with biological age.

What is the Mechanism of Methylation Pattern Correction?

Correction is achieved by providing the necessary enzymatic cofactors and methyl donors, such as folate, B12, and S-adenosylmethionine (SAMe), while also modulating the activity of DNA methyltransferases (DNMTs) and demethylases. A critical focus is the hypermethylation of tumor suppressor genes and the hypomethylation of repetitive elements, both hallmarks of aging. By restoring the precise, youthful methylation landscape, the cell's original, healthy gene expression profile is re-established, promoting cellular identity and stability.

Methylation Pattern Correction ∞ Area

Methylation Pattern Correction

Meaning

The targeted clinical intervention aimed at restoring the correct distribution of methyl groups across the genome, particularly at CpG sites, to reverse the age-associated dysregulation of gene expression. This correction is a primary method for resetting the epigenetic clock and improving cellular function. It is a sophisticated strategy for enhancing longevity and healthspan.