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Metagenomic Shifts

Meaning

Metagenomic Shifts refer to measurable, significant alterations in the collective genetic material and functional capacity of the microbial communities residing within a specific human environment, most notably the gut, skin, or oral cavity. These shifts, often observed in the gut microbiome, are critical because they correlate with changes in the host’s metabolic, immune, and endocrine status. A favorable shift is associated with diversity and beneficial function, while a detrimental shift, known as dysbiosis, can profoundly impact hormonal balance and systemic inflammation. Analyzing these shifts provides a sophisticated, dynamic window into the complex host-microbe relationship and its effect on systemic health.