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Metabotropic Glutamate Receptors

Meaning

Metabotropic Glutamate Receptors, or mGluRs, are a family of G-protein-coupled receptors that modulate the excitability of neurons and synaptic transmission throughout the central nervous system. They are distinguished from ionotropic receptors by their indirect, slower action, serving as crucial fine-tuners of brain activity. These receptors play an important role in neuroplasticity, memory formation, and the regulation of emotional states, acting as key targets for pharmacological intervention in various neurological and psychiatric conditions. Their widespread distribution underscores their fundamental importance in maintaining cerebral balance.