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Metabolic Switch Optimization

Meaning

Metabolic Switch Optimization is the clinical goal of enhancing the body’s innate ability to rapidly and efficiently transition between different primary fuel sources, specifically switching from glucose-based metabolism (glycolysis) to fat-based metabolism (ketogenesis and fatty acid oxidation). This physiological flexibility is a hallmark of metabolic health and resilience, allowing the body to sustain energy production during periods of fasting or high demand. Impaired switching, or metabolic inflexibility, is strongly associated with insulin resistance and age-related chronic diseases.