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Metabolic Stress Buffering

Meaning

Metabolic Stress Buffering refers to the physiological capacity of the body to maintain homeostatic balance and functional integrity in the face of chronic or acute metabolic challenges, such as insulin resistance, nutrient deprivation, or excessive oxidative load. This resilience is a critical determinant of longevity, involving the efficient activation of protective pathways that minimize cellular damage and ensure stable energy production. Optimal hormonal signaling, particularly involving insulin and thyroid hormones, is foundational to this buffering capacity.