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Metabolic Signaling Impairment

Meaning

Metabolic Signaling Impairment describes a defect in the complex cascade of intracellular communication pathways that regulate energy storage, utilization, and expenditure in response to hormonal and nutrient cues. This impairment often manifests as reduced cellular sensitivity to key metabolic hormones, including insulin, leptin, and thyroid hormone, leading to cellular confusion regarding the body’s true energy status. The resulting dysfunction is a fundamental underlying pathology of metabolic syndrome, obesity, and type 2 diabetes.