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Metabolic Signal Override

Meaning

Metabolic Signal Override is a physiological phenomenon where a powerful, dominant signal—often hormonal or nutrient-derived—bypasses or supersedes the typical regulatory control of a less potent metabolic pathway. This override can be intentional, such as using pharmacological agents to force a specific metabolic state, or pathological, as seen in severe insulin resistance where chronic high insulin signaling effectively overrides the body’s ability to engage in fat oxidation. Understanding this hierarchy is essential for effective metabolic manipulation.