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Metabolic Setpoint Establishment

Meaning

Metabolic Setpoint Establishment is the clinical process of resetting the body’s homeostatic energy balance point, often referred to as the “setpoint,” which is the weight or body fat percentage the body strives to maintain through complex regulatory feedback loops. Establishing a new, healthier setpoint requires sustained, coordinated changes in hormonal signaling, appetite regulation, and energy expenditure to overcome the body’s strong resistance to weight loss maintenance. This process is essential for achieving long-term, sustainable body composition changes and metabolic health.