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Metabolic Setpoint Alteration

Meaning

Metabolic Setpoint Alteration describes a fundamental, often persistent, shift in the body’s internally regulated physiological equilibrium for parameters such as body weight, energy expenditure, and glucose homeostasis. This alteration means the body begins to defend a new, typically higher, body weight or a less efficient metabolic state as its new normal, resisting attempts at change through diet or exercise. This change is frequently driven by chronic hormonal dysregulation or early life programming. Understanding this new setpoint is crucial for developing effective, sustainable weight management and metabolic health strategies.