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Metabolic Set Point Fixation

Meaning

The phenomenon where the body’s homeostatic mechanisms, particularly those regulating body weight and energy balance, become rigidly locked onto a specific, often elevated, physiological equilibrium. This fixation makes it highly resistant to change, meaning that the body actively defends this established metabolic state against dietary or exercise interventions. Clinically, this explains the difficulty in sustaining weight loss and the high rate of weight regain after successful dieting.