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Metabolic Set Point Correction

Meaning

Metabolic Set Point Correction is the therapeutic strategy of resetting the hypothalamus-mediated homeostatic mechanisms that regulate body weight, energy expenditure, and hormonal balance, which often become elevated or dysfunctional in chronic metabolic disease. The set point is a tightly regulated physiological range that the body defends, and correction involves sustained interventions to establish a new, healthier equilibrium. This is a critical clinical goal in addressing refractory weight management and metabolic syndrome.