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Metabolic Senolytics

Meaning

Metabolic Senolytics is a novel therapeutic strategy focused on using compounds or interventions that selectively induce apoptosis, or programmed cell death, in senescent cells by targeting their unique metabolic vulnerabilities. Senescent cells are damaged cells that accumulate with age, secrete pro-inflammatory factors, and contribute significantly to tissue dysfunction and chronic disease, including endocrine resistance. The goal of metabolic senolytics is to clear this toxic cellular burden, thereby rejuvenating the tissue microenvironment and potentially reversing age-related hormonal and metabolic decline. This represents a frontier in longevity medicine aimed at manipulating the fundamental processes of biological aging.