A structured, time-limited regimen, often involving specific dietary adjustments, strategic fasting periods, and targeted physical activity, designed to enhance insulin sensitivity and restore homeostatic balance in energy-regulating hormones. The primary clinical goal is to improve cellular responsiveness to metabolic signals, thereby promoting a shift away from fat storage and toward efficient energy utilization. This protocol aims to break cycles of metabolic dysfunction.
Origin
The term is a modern clinical and wellness descriptor for therapeutic interventions rooted in the scientific principles of caloric restriction, intermittent fasting, and exercise physiology. It conceptually frames the intervention as a complete system overhaul rather than a temporary fix. The science behind it lies in modulating key nutrient-sensing pathways.
Mechanism
The protocol operates by strategically inducing periods of low insulin signaling, which activates the AMPK pathway and promotes mitochondrial biogenesis, effectively improving cellular energy efficiency. Reduced glucose and insulin exposure enhances the sensitivity of peripheral tissues, such as muscle and liver, to insulin when it is present. This systemic shift resets the cellular machinery to better process and utilize macronutrients.
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