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Metabolic Programming Error

Meaning

A Metabolic Programming Error is a clinical concept describing a persistent, dysfunctional state in the body’s energy regulation and substrate preference pathways, often initiated early in life or established by prolonged exposure to adverse nutritional and environmental factors. This error results in a systemic bias toward energy storage, insulin resistance, and chronic low-grade inflammation, deviating from the optimal metabolic setpoint. It is not a temporary fluctuation but a deeply entrenched regulatory abnormality that compromises long-term health and endocrine balance. Correcting this error is central to treating chronic metabolic disease.