Skip to main content

Metabolic Neuroprotection

Meaning

Metabolic neuroprotection refers to the physiological and pharmacological strategies aimed at preventing neuronal damage and preserving neurological function by optimizing the brain’s energy metabolism and cellular environment. This concept recognizes the profound dependence of the central nervous system on stable glucose utilization, mitochondrial integrity, and balanced hormonal signaling for its survival and function. In the context of hormonal health, interventions that improve insulin sensitivity or modulate thyroid hormone action in the brain can exert neuroprotective effects, mitigating the risk of cognitive decline and neurodegenerative processes. This approach moves beyond purely structural interventions to target the brain’s fundamental energy pathways.