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Metabolic-Inflammatory-Endocrine Axis

Meaning

The Metabolic-Inflammatory-Endocrine Axis is a sophisticated, bidirectional communication network that describes the inextricable link and mutual influence among the body’s metabolic processes, immune-inflammatory responses, and hormonal signaling systems. Dysfunction in one component invariably perturbs the others, creating a cycle of pathology that underlies many chronic conditions, including obesity, type 2 diabetes, and cardiovascular disease. Clinically, recognizing this integrated axis is essential for treating the root cause of systemic imbalance rather than merely managing individual symptoms.