What is the Origin of Metabolic Inflammation Quantification?

This concept emerged from the intersection of immunology and endocrinology, recognizing that adipose tissue is an active endocrine organ that secretes pro-inflammatory adipokines. It formalized the understanding that chronic, low-level inflammation is not merely a consequence of metabolic disease but a primary driver of its progression. The link between fat tissue and immune signaling is central to this paradigm.

What is the Mechanism of Metabolic Inflammation Quantification?

Adipose tissue expansion, particularly visceral fat, triggers the release of inflammatory cytokines like interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α). These mediators interfere with insulin signaling pathways in the liver and muscle, promoting insulin resistance and contributing to dyslipidemia. This establishes a self-perpetuating cycle of metabolic and inflammatory pathology.

Metabolic Inflammation Quantification ∞ Area

Metabolic Inflammation Quantification

Meaning

Metabolic Inflammation Quantification is the clinical measurement of specific circulating inflammatory mediators and cellular markers to assess the degree of low-grade, chronic systemic immune activation that is mechanistically linked to metabolic dysfunction. This quantification provides an objective metric for “metainflammation,” a state characterized by persistent, non-infectious inflammation that underlies conditions like insulin resistance, visceral adiposity, and Type 2 Diabetes. Key markers often include high-sensitivity C-reactive protein (hs-CRP) and various cytokines.