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Metabolic Homeostatic Setpoints

Meaning

Metabolic Homeostatic Setpoints are the genetically programmed or adaptively established target ranges that the body actively defends for critical physiological variables, including blood glucose, core temperature, and specific circulating hormone levels. The endocrine system utilizes complex feedback loops to continuously steer these variables back toward these setpoints despite internal or external challenges. A drift or loss of rigidity in these setpoints often precipitates chronic metabolic dysfunction. Understanding these targets is central to precision endocrinology.