The duration of an individual’s life characterized by optimal metabolic function, defined by high insulin sensitivity, stable glucose homeostasis, healthy lipid profiles, and efficient energy expenditure. This healthspan is a crucial subset of overall healthspan, representing the period free from metabolic disorders like type 2 diabetes, cardiovascular disease, and non-alcoholic fatty liver disease. Maintaining metabolic healthspan is a primary objective in longevity medicine, as metabolic dysfunction is a central driver of aging.
Origin
This term is a specialized derivation of the broader concept of “healthspan,” which is the period of life spent in good health. “Metabolic” focuses the definition on the biochemical and energy-regulating systems of the body. The clinical emphasis stems from the recognition that metabolic syndrome is a key predictor of premature aging and morbidity.
Mechanism
The preservation of metabolic healthspan is achieved through maintaining high insulin sensitivity at the cellular level, primarily by preserving the function of the insulin receptor and its downstream signaling pathways. This efficiency ensures that glucose is properly stored and utilized, preventing chronic hyperglycemia and the resulting advanced glycation end products (AGEs). Furthermore, it relies on mitochondrial integrity and flexible substrate utilization, allowing the body to efficiently switch between burning fat and carbohydrates for energy.
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