A subjective cognitive impairment characterized by reduced mental clarity, slow processing speed, and difficulty concentrating, frequently linked to underlying systemic metabolic dysregulation.
Origin
This descriptive phrase links clinical neurological complaints with measurable deficits in glucose metabolism or insulin action within the central nervous system.
Mechanism
The pathophysiology often involves impaired cerebral glucose uptake, chronic low-grade neuroinflammation, or insufficient cerebral energy substrates, all secondary to systemic metabolic stress.
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