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Metabolic Health Brain Axis

Meaning

Metabolic Health Brain Axis refers to the bi-directional communication network that links systemic metabolic status, including glucose homeostasis and lipid metabolism, with central nervous system function, encompassing cognitive performance, mood regulation, and neuroinflammation. This critical axis highlights how peripheral endocrine signals, such as insulin, leptin, and adipokines, directly influence neuronal health and function. Maintaining robust metabolic health is therefore paramount for preserving long-term cognitive integrity and neurological resilience. Dysfunction in this axis is implicated in conditions ranging from cognitive decline to neurodegenerative processes.