A systematic, hierarchical classification system used in clinical practice to assess the degree of metabolic dysfunction based on a comprehensive panel of quantitative biomarkers. This staging moves beyond simple diagnosis to categorize an individual’s risk level by evaluating markers like fasting glucose, insulin sensitivity, lipid profile, and inflammatory markers. It provides a precise roadmap for targeted metabolic intervention.
Origin
This methodology is derived from established medical staging systems used in oncology and cardiology, applying a similar risk stratification principle to the field of metabolic health. The term “Staging” implies a progression of risk that can be reversed or mitigated with therapeutic action. It represents a functional medicine approach to assessing the complex interplay of endocrine and metabolic systems.
Mechanism
The staging process operates by correlating the levels of multiple biomarkers to established thresholds for metabolic disease risk, such as insulin resistance and cardiovascular risk. The collective deviation from optimal ranges indicates the severity of underlying cellular and hormonal dysregulation. The mechanism of the system is to provide a quantitative, multi-dimensional view of the body’s energy regulation and inflammatory status.
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