Metabolic Health and Neurology describes the clinical and scientific field that investigates the profound and inseparable relationship between systemic metabolic regulation, including glucose homeostasis and lipid metabolism, and the structure, function, and resilience of the central nervous system. This interdependency highlights that metabolic dysfunction, such as insulin resistance or dyslipidemia, is a significant driver of neuroinflammation and cognitive decline. The clinical focus is on optimizing peripheral metabolic parameters as a primary strategy for preventing and treating neurological and psychiatric disorders. This approach recognizes the brain as a highly metabolically active organ.
Origin
This integrated view emerged from the increasing recognition of metabolic syndrome components as risk factors for neurodegenerative diseases like Alzheimer’s disease, sometimes termed “Type 3 Diabetes.” It is rooted in the understanding that the brain, while protected by the blood-brain barrier, is highly sensitive to fluctuations in circulating hormones, inflammatory mediators, and nutrient availability. The term formalizes the clinical need to address both systems concurrently.
Mechanism
The functional connection operates through several key pathways: chronic hyperglycemia and hyperinsulinemia promote the formation of advanced glycation end products (AGEs), which induce oxidative stress and neuroinflammation. Adipose tissue-derived adipokines and inflammatory cytokines cross the blood-brain barrier, directly impairing synaptic function and neuronal survival. Therapeutic interventions focus on restoring insulin sensitivity, reducing peripheral inflammation, and ensuring optimal delivery of key metabolic substrates to the brain, thereby protecting neuronal integrity and enhancing cognitive performance.
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