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Metabolic Fuel Partitioning

Meaning

Metabolic Fuel Partitioning is the highly regulated physiological process by which the body strategically directs incoming energy substrates—specifically carbohydrates, fats, and proteins—to various metabolic fates. These fates include immediate energy production, long-term storage in adipose tissue, or the synthesis of structural and functional components. This dynamic allocation is tightly governed by key endocrine hormones, notably insulin, glucagon, and cortisol, determining whether the body operates in a predominantly anabolic or catabolic state. Optimal partitioning is absolutely essential for maintaining a healthy body composition, energy balance, and overall metabolic flexibility.