Skip to main content

Metabolic Flexibility Index

Meaning

The Metabolic Flexibility Index is a clinical measure or conceptual indicator of an individual’s capacity to efficiently shift between utilizing different fuel sources, primarily glucose and fatty acids, in response to changes in nutrient availability or energy demand. A high index signifies a robust, adaptive metabolism capable of maintaining stable blood glucose and energy levels under diverse dietary and activity conditions. Conversely, a low index is often clinically associated with insulin resistance, mitochondrial dysfunction, and an increased risk for chronic metabolic disorders.