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Metabolic Flexibility for Mind

Meaning

The brain’s inherent, adaptive capacity to efficiently and rapidly switch between different primary energy substrates, mainly glucose and ketone bodies, to successfully meet its high and often fluctuating energy demands, thereby maintaining consistent cognitive function. This crucial flexibility provides resilience against periods of nutrient scarcity or emerging insulin resistance and is vital for preventing cognitive fatigue and supporting robust neuroplasticity. It is considered a vital and sensitive indicator of overall cerebral metabolic health.