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Metabolic Epigenetics

Meaning

Metabolic Epigenetics explores the profound, reciprocal relationship between the cell’s internal metabolic state and the sophisticated epigenetic machinery that governs gene expression. This field specifically investigates how the cellular availability and flux of key metabolites, such as acetyl-CoA, S-adenosylmethionine (SAM), and NAD+, directly influence the activity of epigenetic enzymes like histone acetyltransferases and DNA methyltransferases. This research provides a crucial molecular link, demonstrating how diet, energy status, and environmental factors are translated into long-term, heritable changes in gene regulation and cellular phenotype.