The network of molecular communications, involving hormones and local factors, that govern the rate and effectiveness with which an organism converts nutrients into usable energy and cellular components. Optimization of this signaling promotes favorable substrate partitioning, often favoring lean mass accretion over ectopic fat deposition. This signaling dictates how well the body handles fuel substrates.
Origin
“Metabolic Efficiency” describes the quality of energy conversion, while “Signaling” refers to the transmission of information between cells, often via chemical messengers. This term originates from endocrinology and cellular physiology, focusing on the regulatory aspect of energy use. It highlights the communication layer of energy homeostasis.
Mechanism
Key signals include insulin, which promotes glucose uptake and storage, and adiponectin, which enhances insulin sensitivity in peripheral tissues. These signals act upon target cells to modulate the activity of key metabolic enzymes and transcription factors governing substrate flux. Effective signaling ensures that nutrients are directed toward constructive processes rather than inflammatory or storage pathways.
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