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Metabolic Dysregulation Pathways

Meaning

Metabolic Dysregulation Pathways refer to the interconnected biochemical and hormonal cascades within the body that, when disturbed, lead to systemic metabolic imbalance and chronic disease states, including insulin resistance, dyslipidemia, and visceral adiposity. These pathways involve the aberrant signaling and function of key metabolic hormones, such as insulin, glucagon, and leptin, and the resultant dysfunction in organs like the liver, muscle, and adipose tissue. Clinical investigation of these pathways provides a detailed understanding of the root causes of metabolic syndrome, moving beyond symptomatic treatment to target the underlying physiological defects. Identifying the specific points of dysregulation is paramount for effective, personalized intervention.