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Metabolic Dysfunction Indicators

Meaning

Metabolic dysfunction indicators are a set of quantifiable clinical and biochemical measurements that signal a breakdown in the body’s ability to process and utilize energy substrates effectively, even before the onset of overt metabolic syndrome or diabetes. These indicators include elevated fasting glucose and insulin, dyslipidemia (high triglycerides, low HDL), increased visceral adiposity, and a high waist-to-hip ratio. They serve as early warning signs of impaired cellular energy regulation and hormonal signaling, particularly insulin resistance. Monitoring these markers is essential for preemptive intervention to mitigate long-term cardiovascular and endocrine risk.