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Metabolic Duress

Meaning

Metabolic Duress describes a state of significant physiological strain where the body’s energy regulatory systems, particularly insulin and glucagon axes, are severely challenged, often due to chronic overnutrition, under-activity, or acute illness. This condition forces endocrine tissues to operate under suboptimal conditions, leading to impaired substrate utilization and potential downstream hormonal dysregulation. Recognizing this duress is critical for preventing progression to chronic metabolic disease.