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Metabolic Dominion

Meaning

Metabolic dominion is a conceptual term describing a state where one specific metabolic pathway or hormonal signal exerts a disproportionately powerful, overriding influence on the body’s overall energy balance, substrate utilization, and physiological function. In the context of hormonal health, this often refers to the powerful regulatory control exerted by hormones like insulin or cortisol, where chronic over-signaling can force other systems into suboptimal function, such as promoting fat storage despite caloric restriction or driving persistent catabolism. Achieving wellness requires re-establishing a balanced, democratic control among the various endocrine and metabolic systems.