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Metabolic Currency Depletion

Meaning

Metabolic Currency Depletion refers to a state of systemic bioenergetic deficit characterized by a profound reduction in the availability of high-energy phosphate compounds, principally Adenosine Triphosphate (ATP), which functions as the universal energy currency of the cell. This severe depletion impairs all fundamental cellular processes, including essential hormone synthesis, active transport mechanisms, and necessary tissue repair, leading to widespread functional decline. It is a hallmark of chronic fatigue syndromes, severe mitochondrial dysfunction, and accelerated biological aging.