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Metabolic Crosstalk

Meaning

Metabolic crosstalk describes the intricate, reciprocal communication and signaling exchanges that occur between different organs and tissues to maintain whole-body energy homeostasis and metabolic stability. This involves the continuous exchange of nutrients, metabolites, hormones, and signaling molecules between key metabolic organs, such as the liver, adipose tissue, skeletal muscle, and the brain. Dysregulation of this precise communication network, often seen in conditions like insulin resistance, is a fundamental driver of chronic metabolic disease. Understanding this network is vital for addressing systemic hormonal and metabolic dysfunction.