What is the Origin of Metabolic Coupling Fidelity?

The term arises from mitochondrial physiology, emphasizing the efficiency of the electron transport chain linking substrate oxidation to phosphorylation.

What is the Mechanism of Metabolic Coupling Fidelity?

High fidelity implies minimal proton leak across the inner mitochondrial membrane, ensuring that substrate oxidation rates directly translate into required ATP generation for cellular work.

Metabolic Coupling Fidelity ∞ Area

Metabolic Coupling Fidelity

Meaning

Metabolic Coupling Fidelity is the precision with which energy production, specifically ATP synthesis via oxidative phosphorylation, aligns with cellular energy demand.