A conceptual framework in clinical endocrinology that describes the collective, integrated regulatory systems governing energy expenditure, substrate utilization, and nutrient storage across multiple organ systems. It represents the homeostatic set point that the body strives to maintain for metabolic equilibrium.
Origin
This is a metaphorical term, combining ‘Metabolic Control’ (the regulation of biochemical processes) and ‘Plane’ (a level or sphere of operation), suggesting a high-level, systemic view of energy governance.
Mechanism
The Control Plane is primarily regulated by the intricate interplay of the hypothalamic-pituitary-adrenal (HPA) axis, pancreatic hormones like insulin and glucagon, and adipokines such as leptin. Optimal function requires precise feedback loops that maintain stable blood glucose, manage fat storage, and ensure adequate energy supply for all physiological demands, adapting dynamically to environmental and internal stressors.
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