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Metabolic Control Layer

Meaning

The metabolic control layer is a conceptual framework describing the foundational, integrated set of physiological mechanisms that govern energy balance, substrate utilization, and nutrient sensing at the cellular and systemic levels. This layer encompasses key regulators such as insulin sensitivity, mitochondrial function, and the activity of metabolic signaling pathways like AMPK and mTOR. Optimizing this control layer is paramount for hormonal health, as dysregulation here often precedes or drives imbalances in the major endocrine axes, including thyroid and sex hormones.