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Metabolic Control Center Sensitivity

Meaning

Metabolic Control Center Sensitivity refers to the responsiveness of key regulatory nuclei in the central nervous system, particularly the hypothalamus, to circulating metabolic signals such as leptin, insulin, and ghrelin. Optimal sensitivity ensures the body can accurately gauge its energy status, appropriately regulate appetite, and maintain glucose and lipid homeostasis. Loss of sensitivity, often termed resistance, leads to a failure in metabolic signaling, contributing directly to conditions like obesity, insulin resistance, and systemic inflammation. Restoring this central sensitivity is a critical target for addressing complex metabolic and hormonal disorders.