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Metabolic Communication

Meaning

Metabolic Communication describes the intricate, continuous process by which cells, tissues, and distant organs exchange information about their nutritional, energetic, and functional status through the release and reception of various signaling molecules. This complex, systemic dialogue ensures precise energy homeostasis, coordinates the actions of disparate organs like the liver, muscle, and adipose tissue, and facilitates adaptive responses to feeding or fasting states. Key messengers in this vital communication network include hormones, cytokines, and small circulating metabolites. Disruptions in this communication are central to the pathogenesis of metabolic syndrome, obesity, and type 2 diabetes.