What is the Origin of Metabolic Cascade?

The term is derived from general systems theory and biochemistry, combining 'metabolic,' relating to the chemical processes occurring within a living organism, with 'cascade,' signifying a rapid, successive, and cumulative chain of events. It is used to describe the flow of energy and matter through the body's systems, emphasizing the domino effect of a single regulatory step on downstream processes.

What is the Mechanism of Metabolic Cascade?

The cascade begins with the ingestion and digestion of macronutrients, which are then broken down into their fundamental components. Hormones like insulin and glucagon act as master regulators, directing the fate of glucose and fatty acids toward either storage or immediate energy use via pathways like glycolysis, the citric acid cycle, and oxidative phosphorylation. A disruption, such as chronic hyperinsulinemia, can trigger a pathological cascade leading to fat storage, inflammation, and cellular energy inefficiency.

Metabolic Cascade

Meaning

A sequential and highly interconnected series of biochemical reactions and enzymatic transformations that occur within the body to maintain life, encompassing anabolism (building up) and catabolism (breaking down) of nutrients, and energy production. This cascade is intricately regulated by hormonal signals, and its proper function is fundamental to energy homeostasis, cellular health, and overall longevity. Dysregulation of this cascade is the hallmark of metabolic syndrome and related chronic diseases.