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Metabolic Burden Persistence

Meaning

Metabolic Burden Persistence refers to the chronic, unremitting demand placed upon the body’s core homeostatic systems, particularly the endocrine and metabolic regulatory networks, due to continuous factors like chronic caloric excess, physical inactivity, and persistent psychological stress. This sustained burden prevents the physiological systems from ever returning to a full resting or repair state, leading to cumulative dysfunction and eventual pathology. It is a central concept for understanding the gradual progression from risk factors to overt metabolic disease, such such as Type 2 diabetes.