Question 1

What is the Meaning of Metabolic Associated Steatohepatitis (MASH)?

Accepted Answer

Metabolic Associated Steatohepatitis (MASH), formerly known as Non-Alcoholic Steatohepatitis (NASH), is a severe form of liver disease characterized by fat accumulation in the liver (steatosis) accompanied by inflammation and hepatocyte injury. This condition is intrinsically linked to metabolic dysfunction, often occurring in individuals with insulin resistance, type 2 diabetes, obesity, and dyslipidemia. MASH can progress to advanced fibrosis, cirrhosis, and ultimately liver failure or hepatocellular carcinoma, representing a significant global health burden. The name change reflects a consensus to emphasize the disease's direct connection to underlying metabolic syndrome, providing a more accurate etiological description.

Question 2

What is the Origin of Metabolic Associated Steatohepatitis (MASH)?

Accepted Answer

The term's precursor, NASH, was coined in 1980 to distinguish the condition from alcoholic liver disease. The transition to Metabolic Associated Steatohepatitis (MASH) occurred through a multi-society consensus in 2023, reflecting a scientific and clinical effort to re-align the nomenclature with the established pathophysiology. The etymology is descriptive: "Metabolic Associated" highlights the root cause, "Steato" refers to fat, "Hepat" refers to the liver, and "itis" denotes inflammation. This shift promotes better clinical clarity and diagnostic precision.

Question 3

What is the Mechanism of Metabolic Associated Steatohepatitis (MASH)?

Accepted Answer

The pathogenesis of MASH is complex and multifactorial, often described by the "multiple-hit" hypothesis, where insulin resistance is the central initiating factor. Insulin resistance leads to increased lipolysis and hepatic de novo lipogenesis, causing the accumulation of triglycerides in hepatocytes. This steatosis then sensitizes the liver to secondary insults, or "hits," such as oxidative stress, mitochondrial dysfunction, and the release of inflammatory cytokines (adipokines) from adipose tissue. The ensuing chronic inflammation and lipotoxicity drive hepatocyte death, triggering the fibrotic response that characterizes advanced MASH.

Metabolic Associated Steatohepatitis (MASH)

Meaning

Origin

Mechanism

What Are the Long-Term Safety Considerations for Peptide Therapies in Glucose Management?

Provided by the clinical team
at 4Ever Young Miami Dadeland

-15% ∞ HRTIO15

Your protocol begins with a conversation.

Visit

Schedule Appointment

About

Med & Wellness

4Ever Young Miami Dadeland

Communication

+1 786-529-6686

Email Us

Opening Hours