What is the Origin of Metabolic Aging?

The concept bridges gerontology and metabolism, focusing on the deterioration of cellular energy systems as a core mechanism of biological decline. The term emphasizes that the aging process is not merely chronological but is fundamentally driven by a decline in metabolic health.

What is the Mechanism of Metabolic Aging?

Metabolic aging is driven by chronic low-grade inflammation, oxidative stress, and the accumulation of cellular damage. Specifically, the mechanisms include a decrease in mitochondrial biogenesis and efficiency, leading to reduced ATP production, and impaired insulin signaling, which causes glucose intolerance. This systemic inefficiency leads to energy deficits and poor tissue repair.

Metabolic Aging ∞ Area

Metabolic Aging

Meaning

The cumulative, progressive decline in the efficiency and capacity of cellular energy production and substrate utilization that occurs over an individual’s lifespan. This process is characterized by increasing insulin resistance, mitochondrial dysfunction, and a shift toward less efficient energy expenditure. Effectively managing metabolic aging is critical for preventing age-related chronic diseases like type 2 diabetes and cardiovascular disease.