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Metabolic Adaptation Mitigation

Meaning

Metabolic adaptation mitigation refers to clinical and nutritional strategies specifically employed to counteract the decrease in resting energy expenditure that often occurs during prolonged caloric restriction or weight loss. When the body perceives a state of energy deficit, it defensively lowers its metabolic rate to conserve energy and prevent starvation, a phenomenon known as metabolic adaptation. Mitigation efforts are crucial for overcoming weight loss plateaus and preventing weight regain, focusing on preserving thyroid function, maintaining muscle mass, and optimizing leptin and ghrelin signaling.