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Meta-Analyses

Meaning

Meta-analyses are rigorous, high-level statistical methodologies that systematically combine the quantitative results from multiple independent clinical studies, typically randomized controlled trials, that have investigated the same question regarding a specific intervention or hormonal effect. This sophisticated process involves pooling data to generate a single, more powerful estimate of the true effect size, providing the highest level of evidence in the clinical hierarchy for determining the efficacy and safety of a therapeutic approach in endocrinology. They serve as a critical tool for synthesizing fragmented research findings.