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Menopause Epigenetic Impact

Meaning

Menopause epigenetic impact refers to the significant, measurable changes in DNA methylation patterns and other epigenetic marks that are triggered by the sharp, permanent decline in ovarian hormone production during the menopausal transition. This hormonal shift acts as a profound environmental signal within the body, leading to widespread alterations in gene expression across various tissues, notably in the brain, bone, and cardiovascular system. These epigenetic changes are hypothesized to be a core driver of the accelerated aging and increased risk for chronic diseases observed post-menopause.