A comprehensive approach focused on enhancing the neurobiological processes of encoding, consolidation, storage, and retrieval of information within the central nervous system. This support is achieved through targeted interventions that bolster synaptic plasticity and promote the structural health of memory-critical brain regions, most notably the hippocampus and associated cortical networks. It is a primary goal for maintaining cognitive vitality across the lifespan.
Origin
This concept is foundational to cognitive neuroscience and education, drawing from decades of research into the cellular and molecular basis of learning, primarily long-term potentiation (LTP). Clinical application translates this knowledge into practical strategies for improving real-world cognitive performance. Hormones and nutrition are recognized as powerful modulators of these processes.
Mechanism
Effective support relies on optimizing the function of neurotransmitter systems, especially the cholinergic and glutamatergic pathways, which are essential for synaptic communication and plasticity. Key mechanisms involve ensuring adequate substrate for neuronal membrane synthesis and mitochondrial function to meet the high energy demands of memory consolidation. Hormones like estrogen and thyroid hormone directly regulate the density of dendritic spines, physically enhancing the brain’s capacity for learning.
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