What is the Meaning of Melatonin Suppression?

Melatonin suppression is the physiological phenomenon where the synthesis and secretion of the hormone melatonin by the pineal gland are inhibited, most notably by exposure to short-wavelength visible light, particularly blue light. This acute reduction in circulating melatonin levels disrupts the body's internal circadian rhythm and signaling related to the sleep-wake cycle. Chronic suppression can negatively impact sleep quality, metabolic function, and antioxidant capacity.

What is the Origin of Melatonin Suppression?

The term combines 'melatonin,' a compound of melas (black) and tonos (tension) referencing its role in skin darkening and biological tone, with 'suppression,' from the Latin supprimere, meaning "to press down." The phenomenon was scientifically identified through research into the photic regulation of the pineal gland's endocrine function. It is a critical concept in chronobiology and sleep medicine.

What is the Mechanism of Melatonin Suppression?

The mechanism is mediated by the retinohypothalamic tract, a neural pathway that transmits light signals from specialized photoreceptor cells in the retina to the suprachiasmatic nucleus (SCN), the body's master clock. From the SCN, inhibitory signals are sent to the pineal gland, preventing the nocturnal activation of the enzyme arylalkylamine N-acetyltransferase (AANAT), which is rate-limiting for melatonin synthesis. Exposure to light at night effectively mimics daytime signaling, thereby acutely halting the hormone's production.

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