What is the Origin of Melatonin Suppression Protocol?

The protocol originates from chronobiology and sleep medicine research, where melatonin's role as the primary hormone signaling darkness and regulating the sleep-wake cycle is well-established. The etymological basis lies in the photic inhibition of melatonin synthesis, a highly conserved biological response across species. Clinical application allows for resetting the body's internal clock, particularly in cases of jet lag or shift work disorder.

What is the Mechanism of Melatonin Suppression Protocol?

The suppression mechanism is mediated by intrinsically photosensitive retinal ganglion cells (ipRGCs) in the eye, which contain the photopigment melanopsin and are highly sensitive to blue light wavelengths. Upon light exposure, these cells signal the suprachiasmatic nucleus (SCN), which in turn sends inhibitory signals via the sympathetic nervous system to the pineal gland. This inhibitory signal blocks the final enzymatic step in melatonin synthesis, causing a rapid and profound drop in circulating hormone levels.

Melatonin Suppression Protocol

Meaning

Melatonin Suppression Protocol is a deliberate clinical or research strategy employing specific light exposure, often blue-spectrum light, at critical times to acutely inhibit the nocturnal production and secretion of the hormone melatonin by the pineal gland. This protocol is utilized to manipulate the circadian rhythm, test pineal function, or prepare a patient for chronotherapy interventions. It requires precise control over light wavelength, intensity, and timing.