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Melatonin Signaling Fidelity

Meaning

Melatonin Signaling Fidelity refers to the integrity and effectiveness of the biological pathway by which the hormone melatonin transmits its regulatory signals to target cells throughout the body. High fidelity indicates that melatonin, secreted rhythmically by the pineal gland, binds effectively to its receptors (MT1 and MT2) and successfully initiates the appropriate downstream cellular responses, such as promoting sleep, acting as an antioxidant, and regulating immune function. Diminished fidelity, often due to receptor desensitization or low nocturnal melatonin production, compromises the body’s ability to execute crucial restorative and regulatory processes.